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The concomitant utilization of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors could lead to a rise in methadone plasma concentrations, which could result in most likely lethal respiratory melancholy. Furthermore, discontinuation of concomitantly utilized cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers can also result in a